{"id":9310,"date":"2024-09-15T15:26:16","date_gmt":"2024-09-15T15:26:16","guid":{"rendered":"http:\/\/philosophers.org\/ckf\/?p=9310"},"modified":"2024-09-15T15:26:20","modified_gmt":"2024-09-15T15:26:20","slug":"the-end-of-alzheimers-programthe-first-protocol-to-enhance-cognition-and-reverse-decline-at-any-age","status":"publish","type":"post","link":"http:\/\/philosophers.org\/ckf\/2024\/09\/15\/the-end-of-alzheimers-programthe-first-protocol-to-enhance-cognition-and-reverse-decline-at-any-age\/","title":{"rendered":"The End of Alzheimer’s ProgramThe First Protocol to Enhance Cognition and Reverse Decline at Any Age"},"content":{"rendered":"\n

\u7576\u9762\u5c0d\u76ee\u524d\u7121\u6cd5\u6cbb\u7652\u7684\u75be\u75c5\uff08\u4f8b\u5982\u963f\u8332\u6d77\u9ed8\u75c7\uff09\u6642\uff0c\u60a3\u8005\u548c\u5bb6\u4eba\u901a\u5e38\u6703\u5728\u91ab\u751f\u8fa6\u516c\u5ba4\u4e4b\u5916\u5c0b\u627e\u5e0c\u671b\u3002\u8a3a\u65b7\u7d50\u679c\u53ef\u80fd\u6703\u4ee4\u4eba\u6050\u61fc\uff0c\u53ef\u4ee5\u7406\u89e3\u7684\u662f\uff0c\u6709\u4e9b\u4eba\u6703\u7a4d\u6975\u5c0b\u6c42\u4efb\u4f55\u8072\u7a31\u6709\u6548\u7684\u5e72\u9810\u63aa\u65bd\u3002\u96a8\u8457\u76f4\u63a5\u9762\u5411\u6d88\u8cbb\u8005\u7684\u7661\u5446\u75c7\u5e72\u9810\u63aa\u65bd\u84ec\u52c3\u767c\u5c55\uff0c\u56e0\u6b64\u9700\u8981\u56b4\u683c\u8a55\u4f30\u652f\u6301\u9019\u4e9b\u9078\u64c7\u7684\u8b49\u64da\u3002<\/p>\n\n\n\n

Dale Bredesen \u6240\u8457\u7684 \u201cThe End of Alzheimer’s Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age<\/a>\u201d <\/em>\u4e00\u66f8\u56de\u9867\u4e86\u4ed6\u7684\u540c\u540d\u65b9\u6848 Bredesen Protocol\uff0c\u526f\u6a19\u984c\u662f \u201c\u7b2c\u4e00\u500b\u9810\u9632\u548c\u9006\u8f49\u8a8d\u77e5\u8870\u9000\u7684\u8a08\u5283\u201d<\/em>\u3002Bredesen \u65b9\u6848\u63d0\u4f9b\u4e86\u4e00\u500b\u5c07\u591a\u7a2e\u81b3\u98df\u88dc\u5145\u5291\u8207\u8a73\u7d30\u7684\u751f\u6d3b\u65b9\u5f0f\u6539\u8b8a\u548c\u5176\u4ed6\u6709\u91dd\u5c0d\u6027\u7684\u5e72\u9810\u63aa\u65bd\uff08\u4f8b\u5982\u5c0d\u6297\u767c\u708e\u548c\u6bd2\u7d20\uff09\u76f8\u7d50\u5408\u7684\u8a08\u5283\u3002\u5118\u7ba1\u5be6\u65bd\u7684\u81ea\u4ed8\u8cbb\u7528\u5f88\u9ad8\uff0c\u4f46\u8a72\u65b9\u6848\u5df2\u7d93\u8d8a\u4f86\u8d8a\u53d7\u6b61\u8fce\uff0c\u800c\u4e14\u8a72\u66f8\u51fa\u73fe\u5728\u8a31\u591a\u66a2\u92b7\u66f8\u6392\u884c\u699c\u4e0a\uff0c\u5305\u62ec\u300a\u7d10\u7d04\u6642\u5831\u300b<\/em>\u3001\u300a\u83ef\u723e\u8857\u65e5\u5831\u300b<\/em>\u548c\u4e9e\u99ac\u905c\u7db2\u7ad9\u3002\u63a8\u85a6 Bredesen \u65b9\u6848\u7684\u91ab\u751f\u7d93\u5e38\u5f15\u7528 Bredesen \u767c\u8868\u7684\u4e09\u9805\u7814\u7a76\uff0c\u4ee5\u53ca\u4ed6\u8207\u53d7\u4eba\u5c0a\u656c\u7684\u5b78\u8853\u91ab\u7642\u4e2d\u5fc3\u7684\u95dc\u4fc2\u3002\u5118\u7ba1\u6c92\u6709\u5176\u4ed6\u65b9\u6cd5\u88ab\u8b49\u660e\u53ef\u4ee5\u660e\u78ba\u9810\u9632\u6216\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\uff0c\u4f46 Bredesen \u65b9\u6848\u5f37\u70c8\u8072\u7a31\u5176\u529f\u6548 \uff1b\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u4ed4\u7d30\u8a55\u4f30\u73fe\u6709\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u78ba\u5b9a\u6307\u5c0e\u65b9\u6848\u7684\u8b49\u64da\u5f37\u5ea6 \u3002<\/p>\n\n\n\n

I.<\/p>\n\n\n\n

\u201cThe End of Alzheimer’s Program\u201d<\/em> \u662f\u4e00\u672c\u91cd\u8981\u7684\u66f8\u3002\u6539\u8b8a\u751f\u6d3b\u65b9\u5f0f\uff08\u5305\u62ec\u71df\u990a\uff09\u5c0d\u5065\u5eb7\u7684\u76ca\u8655\u65e9\u5df2\u70ba\u4eba\u6240\u77e5\u3002\u964d\u4f4e\u5fc3\u81df\u75c5\u3001\u764c\u75c7\u548c\u4e2d\u98a8\u7684\u98a8\u96aa\u6fc0\u52f5\u4e86\u8a31\u591a\u60a3\u8005\uff0c\u4f46\u4e0d\u8db3\u4ee5\u4f7f\u4eba\u53e3\u66f4\u5065\u5eb7\u3002\u907f\u514d\u751a\u81f3\u9006\u8f49\u963f\u8332\u6d77\u9ed8\u75c7\u5247\u662f\u53e6\u4e00\u56de\u4e8b\u3002\u6c92\u6709\u4eba\u5e0c\u671b\u81ea\u5df1\u6216\u89aa\u4eba\u7684\u751f\u547d\u4ee5\u591a\u5e74\u7684\u7661\u5446\u75c7\u7d50\u675f\u3002<\/p>\n\n\n\n

\u4e09\u5206\u4e4b\u4e00\u7684\u7f8e\u570b\u4eba\u5c07\u5728 85 \u6b72\u6642\u60a3\u4e0a\u963f\u8332\u6d77\u9ed8\u75c7\u6216\u5176\u4ed6\u5f62\u5f0f\u7684\u7661\u5446\u75c7 (Alzheimer\u2019s Association. 2017 Alzheimer\u2019s Disease Facts and Figures<\/a>)\u3002\u963f\u8332\u6d77\u9ed8\u75c7\u548c\u5176\u4ed6\u5f62\u5f0f\u7684\u5931\u667a\u75c7\u8207\u6211\u5011\u7684\u71df\u990a\u548c\u5176\u4ed6\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u6709\u95dc\uff0c\u751a\u81f3\u8207 ApoE4<\/a> \u57fa\u56e0\u8b8a\u7570\u6709\u95dc \u3002\u9019\u672c\u66f8\u8868\u660e\uff0c\u5982\u679c\u53ca\u65e9\u767c\u73fe\uff0c\u963f\u8332\u6d77\u9ed8\u75c7\u662f\u53ef\u4ee5\u9810\u9632\u751a\u81f3\u9006\u8f49\u7684\u3002<\/p>\n\n\n\n

Dale Bredesen \u662f\u4e00\u4f4d\u57fa\u790e\u79d1\u5b78\u5bb6\u548c\u795e\u7d93\u5b78\u5bb6\uff0c\u5728\u5be6\u9a57\u5ba4\u5de5\u4f5c\u4e86 20 \u591a\u5e74\uff0c\u7814\u7a76\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u751f\u7269\u5b78\u3002\u548c\u8a31\u591a\u4eba\u4e00\u6a23\uff0c\u4ed6\u5e0c\u671b\u627e\u5230\u55ae\u4e00\u7684\u751f\u5316\u65b9\u6cd5\u4f86\u6cbb\u7642\u9019\u7a2e\u4f7f\u4eba\u8870\u5f31\u7684\u75be\u75c5\u3002\u5728\u4ed6\u7684\u66f8\u4e2d\uff0c\u4ed6\u89e3\u91cb\u4e86\u70ba\u4ec0\u9ebc\u9019\u662f\u4e0d\u53ef\u80fd\u7684\u3002\u64da\u4ed6\u4e86\u89e3\uff0c\u60a3\u6709\u963f\u8332\u6d77\u9ed8\u75c7\u5c31\u50cf\u5c4b\u9802\u6f0f\u6c34 \uff0c\u6709 36 \u500b\u6d1e\u3002\u4fee\u5fa9\u4e00\u500b\u4e26\u4e0d\u80fd\u89e3\u6c7a\u554f\u984c\u3002\u7136\u800c\uff0c\u4ed6\u7684\u63a5\u53d7\u904e\u529f\u80fd\u91ab\u5b78\u57f9\u8a13\u4e26\u5f9e\u4e8b\u529f\u80fd\u91ab\u5b78\u5be6\u8e10\u7684\u5bb6\u5ead\u91ab\u751f\u7684\u59bb\u5b50\u544a\u8a34\u4ed6\uff0c\u6cbb\u7642\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u552f\u4e00\u65b9\u6cd5\u662f\u6539\u8b8a\u751f\u6d3b\u65b9\u5f0f\u3002\u4ed6\u6c7a\u5b9a\u9032\u884c\u4e00\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u900f\u904e\u5f37\u5316\u751f\u6d3b\u65b9\u5f0f\u6539\u8b8a\u4f86\u6539\u5584\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u3002 Bredesen \u5c08\u9580\u7528\u4e86\u4e00\u7ae0\u4f86\u4ecb\u7d39 \u201c\u96f6\u865f\u75c5\u4eba\u201d\uff0c\u5176\u6539\u5584\u60c5\u6cc1\u65bc 2014 \u5e74\u767c\u8868 (Bredesen DE. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014;6(9):707-717<\/a>)\u3002<\/p>\n\n\n\n

\u5f9e\u90a3\u6642\u8d77\uff0cBredesen \u5ba3\u7a31\u5df2\u7d93\u5728 200 \u591a\u540d\u60a3\u8005\u8eab\u4e0a\u986f\u793a\u51fa\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u6539\u5584\u6216\u9006\u8f49 \u3002\u4ed6\u5728\u5f8c\u7e8c\u8ad6\u6587\u4e2d\u5831\u544a\u4e86\u5176\u4e2d\u7684\u4e00\u4e9b\u5167\u5bb9 (Bredesen DE, Amos EC, Canick J, et al. Reversal of cognitive decline in Alzheimer\u2019s disease. Aging (Albany NY). 2016 ; 8(6) : 1250-1258<\/a>.)\u3002\u4ed6\u63cf\u8ff0\u4e86\u4ed6\u5728\u70ba\u9019\u9805\u5de5\u4f5c\u7372\u5f97\u7814\u7a76\u7d93\u8cbb\u6642\u9047\u5230\u4e86\u591a\u5c11\u9ebb\u7169\uff0c\u56e0\u70ba\u4ed6\u6c92\u6709\u63d0\u51fa\u55ae\u4e00\u7684\u89e3\u6c7a\u65b9\u6848\u3002\u4ed6\u7684\u65b9\u6848\u662f\u7d93\u904e\u5927\u7d04 5 \u5e74\u7684\u60a3\u8005\u7814\u7a76\u800c\u88fd\u5b9a\u7684\uff0c\u88ab\u7a31\u70ba ReCODE\uff08\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d reversing cognitive decline<\/a>\uff09\uff0c\u5373 Bredesen \u65b9\u6848 3.0\u3002\u900f\u904e\u9019\u672c\u66f8\u548c\u4ed6\u7684\u7db2\u7ad9 drbredesen.com \u548c mpicognition.com\uff0c\u4ed6\u6b63\u5728\u57f9\u8a13\u5f9e\u696d\u8005\u5728\u4e16\u754c\u5404\u5730\u63d0\u4f9b\u8a72\u65b9\u6848\u3002<\/p>\n\n\n\n

\u5f9e\u5c0d\u60a3\u8005\u9032\u884c\u8a55\u4f30\u958b\u59cb\uff0cDale Bredesen \u5efa\u8b70\u63a1\u7528\u5fb9\u5e95\u7684\u6e2c\u8a66\u65b9\u6848\uff0c\u4ed6\u7a31\u4e4b\u70ba \u201c\u8a8d\u77e5\u6aa2\u67e5cognoscopy\u201d \u3002\u9019\u5305\u62ec\u9ad4\u7a4d MRI\u3001\u57fa\u56e0\u6e2c\u8a66\u548c\u5f9e MoCA<\/a>\uff08\u8499\u7279\u5229\u723e\u8a8d\u77e5\u8a55\u4f30 Montreal Cognitive Assessment\uff09\u958b\u59cb\u7684\u5168\u9762\u795e\u7d93\u8a8d\u77e5\u6e2c\u8a66\u3002\u5efa\u8b70\u9032\u884c\u5ee3\u6cdb\u7684\u5be6\u9a57\u5ba4\u5de5\u4f5c\uff0c\u5305\u62ec\u767c\u708e\u6a19\u8a18\u3002 Bredesen \u63cf\u8ff0\u4e86\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u4e09\u7a2e\u4e9e\u578b\uff1a(1) \u767c\u708e\u578b Inflammatory\uff08\u71b1\u578b\uff09\u5305\u62ec\u5177\u6709 ApoE4 \u57fa\u56e0\u578b\u7684\u4e9e\u578b\uff1b(2) \u840e\u7e2e\u578b Atrophic\uff08\u51b7\u578b\uff09\uff1b(3) \u6bd2\u6027\u578b Toxic\uff08\u63a5\u89f8\u5316\u5b78\u54c1\u548c\u611f\u67d3\uff09\u3002\u9019\u4e9b\u985e\u578b\u900f\u904e\u6aa2\u6e2c\u5f97\u5230\u660e\u78ba\uff0c\u4e00\u4e9b\u60a3\u8005\uff0c\u5c24\u5176\u662f\u5177\u6709 ApoE4 \u57fa\u56e0\u578b\u7684\u60a3\u8005\uff0c\u5177\u6709 1 \u578b\u548c 2 \u578b\u7684\u7d44\u5408\u3002<\/p>\n\n\n\n

ReCODE \u65b9\u6848\u5f37\u8abf\u71df\u990a\uff0c\u4f46\u4e5f\u5305\u62ec\u904b\u52d5\u3001\u7761\u7720\u548c\u6e1b\u58d3\u3002\u71df\u990a\u662f\u6bcf\u5929\u81f3\u5c11\u7981\u98df 12 \u5c0f\u6642\u4ee5\u9054\u5230\u916e\u75c7 ketosis \u4e26\u4e14\u7a7a\u8179\u80f0\u5cf6\u7d20\u6c34\u5e73\u70ba 4.5 \u6216\u66f4\u4f4e\u3002\u7a7a\u8179\u8840\u7cd6\u61c9\u4f4e\u65bc 90\uff0c\u7cd6\u5316\u8840\u7d05\u7d20\u61c9\u4f4e\u65bc 5.6%\u3002\u98df\u7269\u9078\u64c7\u662f\u4f4e\u8840\u7cd6\u5730\u4e2d\u6d77\u98f2\u98df\uff0c\u542b\u6709\u6a44\u6b16\u6cb9\u548c\u5927\u91cf\u852c\u83dc\u548c\u6574\u500b\u6c34\u679c\u3002\u5bb6\u79bd\u548c\u96de\u86cb\u61c9\u8a72\u662f\u7267\u5834\u98fc\u990a\u7684\uff0c\u5176\u4ed6\u8089\u985e\u662f\u8349\u98fc\u7684\uff0c\u4e26\u7528\u4f5c\u8abf\u5473\u54c1\u800c\u4e0d\u662f\u4e3b\u83dc\u3002\u6d77\u9bae\u61c9\u8a72\u662f\u91ce\u751f\u7684\uff0c\u70ba\u4e86\u907f\u514d\u6c5e\u548c\u5176\u4ed6\u6bd2\u7d20\uff0c\u61c9\u907f\u514d\u98df\u7528\u9bca\u9b5a\u3001\u65d7\u9b5a\u548c\u9baa\u9b5a\u7b49\u5927\u5634\u9b5a\u3002\u4ed6\u63a8\u85a6\u300cSMASH\u300d\u9b5a\uff1a\u9bad\u9b5a salmon\u3001\u9bd6\u9b5a mackerel\u3001\u9bf7\u9b5a anchovies\u3001\u6c99\u4e01\u9b5a sardines \u548c\u9be1\u9b5a herring\u3002Dale Bredesen \u63a8\u85a6\u4e86\u8a31\u591a\u7b26\u5408\u529f\u80fd\u91ab\u5b78\u65b9\u6cd5\u7684\u88dc\u5145\u5291\u3002\u6211\u6578\u4e86\u6578\u8d85\u904e 20 \u7a2e\u88dc\u5145\u5291\uff0cBredesen \u5efa\u8b70\u4e00\u500b\u4eba\u4e0d\u9700\u8981\u7acb\u5373\u958b\u59cb\u4f7f\u7528\u6240\u6709\u88dc\u5145\u5291\u3002<\/p>\n\n\n\n

\u5f9e\u5f88\u591a\u65b9\u9762\u4f86\u8aaa\uff0c\u201cThe End of Alzheimer’s Program\u201d<\/em> \u6216\u8005\u7b97\u662f\u5bb6\u5ead\u91ab\u5b78\u7684\u52dd\u5229\uff0c\u5728\u7f8e\u570b\u6709\u5bb6\u5ead\u91ab\u751f\u5728\u60a3\u8005\u8eab\u4e0a\u4f7f\u7528\u5b83\u3002\u751a\u81f3\u5728\u67d0\u4e9b\u91ab\u7642\u4e2d\u5fc3\u958b\u59cb\u5be6\u8e10 (\u00a0\u5982 Eisenhower Medical Center<\/a>\u00a0)\uff0c\u91cd\u9ede\u662f\u529f\u80fd\u91ab\u5b78\uff0c\u4ee5\u88dc\u5145\u5bb6\u5ead\u91ab\u5b78\u3002\u4e00\u4e9b\u4eba\u63a5\u53d7 Bredesen \u65b9\u6848 3.0 \u7684\u6b63\u5f0f\u57f9\u8a13\u3002\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u662f\u91ab\u5b78\u9818\u57df\u7684\u904a\u6232\u898f\u5247\u6539\u8b8a\u8005\uff0c\u5c6c\u65bc\u521d\u7d1a\u4fdd\u5065\u9818\u57df\u3002Loma Linda \u5927\u5b78\u7684\u5169\u4f4d\u795e\u7d93\u79d1\u91ab\u751f\u662f\u4e00\u5c0d\u592b\u59bb\uff0c\u8ca0\u8cac\u6307\u5c0e Loma Linda \u5927\u5b78\u91ab\u5b78\u4e2d\u5fc3\u7684\u5927\u8166\u5065\u5eb7\u548c\u963f\u8332\u6d77\u9ed8\u75c7\u9810\u9632\u8a08\u756b\u3002\u4ed6\u5011\u4f3c\u4e4e\u4e5f\u8b49\u660e\u4e86\u900f\u904e\u985e\u4f3c\u7684\u751f\u6d3b\u65b9\u5f0f\u53ef\u4ee5\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u3002\u552f\u4e00\u771f\u6b63\u7684\u5340\u5225\u662f\u4ed6\u5011\u7684\u98f2\u98df\u4ee5\u5168\u690d\u7269\u98df\u54c1\u70ba\u4e3b\uff0c\u907f\u514d\u4f7f\u7528\u6240\u6709\u52d5\u7269\u7522\u54c1\u3002\u552f\u4e00\u63a8\u85a6\u7684\u88dc\u5145\u5291\u662f\u7dad\u751f\u7d20 B12 \u548c\u9b5a\u6cb9\u3002\u4ed6\u5011\u4e5f\u63a8\u85a6\u6bcf\u5929\u9032\u884c\u8a8d\u77e5\u7df4\u7fd2\u3002\u4ed6\u5011\u7684\u66f8\u6bd4 Dale Bredesen \u7684\u66f8\u665a\u4e09\u9031\u51fa\u7248 (Sherzai D, Sherzai A. \u201cThe Alzheimer\u2019s Solution (2017)<\/a>\u201d<\/em> )\u3002\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u4f86\u95e1\u660e\u4ec0\u9ebc\u662f\u6709\u6548\u7684\uff0c\u4f46\u73fe\u5728\u6700\u91cd\u8981\u7684\u662f\u8981\u77e5\u9053\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u662f\u53ef\u9006\u7684\uff0c\u800c\u751f\u6d3b\u65b9\u5f0f\u7684\u6539\u8b8a\u5c31\u662f\u7b54\u6848\u3002<\/p>\n\n\n\n

II.<\/p>\n\n\n\n

\u8eab\u70ba\u8a8d\u77e5\u795e\u7d93\u5b78\u5bb6\u7684 Dale Bredesen \u6240\u8457\u7684 \u201cThe End of Alzheimer’s Program\u201d<\/em> \u4e00\u66f8\u3002\u5728\u7814\u7a76\u8a2d\u8a08\u65b9\u9762\uff0c\u4ee5 Bredesen \u70ba\u7b2c\u4e00\u4f5c\u8005\u7684\u4e09\u7bc7\u79d1\u5b78\u8ad6\u6587\uff082014 \u5e74<\/a> (Reversal of cognitive decline- A novel therapeutic program)\u30012016 \u5e74<\/a> (Reversal of cognitive decline in Alzheimer\u2019s disease) \u548c 2018 \u5e74<\/a>(reversal-of-cognitive-decline-100-patients-2161-0460-1000450) \uff09\u90fd\u662f\u81e8\u5e8a\u75c5\u4f8b\u7cfb\u5217\uff0c\u63cf\u8ff0\u4e86\u63a1\u7528\u4ed6\u7684\u5e72\u9810\u63aa\u65bd\u7684\u53c3\u8207\u8005\u7684\u7d50\u679c\u3002\u75c5\u4f8b\u7cfb\u5217\u672c\u8cea\u4e0a\u662f\u4e00\u7a2e\u63cf\u8ff0\u6027\u7814\u7a76\uff0c\u63d0\u4f9b\u7684\u8b49\u64da\u6709\u9650\uff0c\u4e26\u4e14\u5728\u7528\u65bc\u8b49\u660e\u85e5\u7269\u6cbb\u7642\u7684\u6709\u6548\u6027\u6642\u5b58\u5728\u554f\u984c\u3002\u75c5\u4f8b\u7cfb\u5217\u7121\u6cd5\u6e96\u78ba\u8a55\u4f30\u65b0\u7642\u6cd5\u7684\u6548\u679c\uff0c\u56e0\u70ba\u5b83\u5011\u4e26\u975e\u65e8\u5728\u6aa2\u9a57\u5047\u8a2d\u3002\u76f8\u53cd\uff0c\u5c0d\u7167\u7d44\u548c\u96a8\u6a5f\u5316\u7684\u81e8\u5e8a\u8a66\u9a57\u9069\u5408\u7528\u4f86\u78ba\u5b9a\u65b0\u6cbb\u7642\u4ecb\u5165\u7684\u7642\u6548\u3002\u5118\u7ba1\u672c\u66f8\u7684\u526f\u6a19\u984c\u63a8\u65b7\u51fa\u78ba\u5b9a\u6027\uff0c\u4f46\u5c1a\u7121\u5df2\u767c\u8868\u7684\u7814\u7a76\u6e2c\u8a66\u6216\u8b49\u660e Bredesen \u65b9\u6848\u53ef\u4ee5\u9810\u9632\u548c\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u5047\u8a2d\u3002\u4ed6\u7684\u7814\u7a76\u8a2d\u8a08\u8207\u6240\u63cf\u8ff0\u7684\u7279\u5b9a\u5e72\u9810\u63aa\u65bd\u76f8\u7d50\u5408\uff0c\u4e5f\u5448\u73fe\u51fa\u5b89\u6170\u5291\u6548\u61c9\u7684\u5de8\u5927\u6f5b\u529b\u3002\u7576\u4ecb\u5165\u63aa\u65bd\u65b0\u7a4e\u3001\u8907\u96dc\u3001\u6602\u8cb4\u3001\u5177\u6709\u8f03\u9ad8\u5730\u4f4d\u7684\u54c1\u724c\u4e26\u4e14\u671f\u671b\u53c3\u8207\u8005\u6216\u63d0\u4f9b\u8005\u53d7\u76ca\u6642\uff0c\u5b89\u6170\u5291\u53ef\u4ee5\u5c0d\u60a3\u8005\u6539\u5584\u7522\u751f\u66f4\u5927\u7684\u6548\u679c\u3002\u7814\u7a76\u8a2d\u8a08\u7684\u53e6\u4e00\u500b\u8003\u616e\u56e0\u7d20\u662f\uff0c\u75c5\u4f8b\u7cfb\u5217\u5f88\u5bb9\u6613\u53d7\u5230\u7d0d\u5165\u6216\u6392\u9664\u53c3\u8207\u8005\u7684\u9078\u64c7\u504f\u5dee\u7684\u5f71\u97ff\u3002<\/p>\n\n\n\n

\u9664\u4e86\u7814\u7a76\u8a2d\u8a08\u4e4b\u5916\uff0c\u9019\u4e09\u7bc7\u6587\u7ae0\u4e2d\u7684\u56b4\u91cd\u554f\u984c\u4e5f\u9650\u5236\u4e86\u79d1\u5b78\u7684\u54c1\u8cea\u3002<\/p>\n\n\n\n

\u8a55\u4f30 Bredesen \u65b9\u6848\u7684\u4e09\u7bc7\u79d1\u5b78\u6587\u7ae0\u7684\u7126\u9ede\u7e3d\u7d50\u3002(\u6ce8\u610f\u4e8b\u9805\u548c\u9650\u5236 VS \u5f71\u97ff)<\/p>\n\n\n\n

    \n
  1. \u6848\u4f8b\u7cfb\u5217\uff0c\u63cf\u8ff0\u6027\u7814\u7a76\u8a2d\u8a08 : \u89c0\u5bdf\u6578\u64da\u4e26\u975e\u65e8\u5728\u6aa2\u9a57\u5047\u8a2d\u4e26\u63d0\u4f9b\u6709\u9650\u7684\u529f\u6548\u8b49\u64da\uff084 \u7d1a\uff0cC \u7d1a\uff09\u3002\u9ad8\u5ea6\u5bb9\u6613\u53d7\u5230\u9078\u64c7\u504f\u5dee\u548c\u5b89\u6170\u5291\u6548\u61c9\u7684\u5f71\u97ff<\/li>\n\n\n\n
  2. \u5831\u544a\u4e0d\u5305\u62ec\u65b9\u6cd5\u90e8\u5206: \u53c3\u8207\u8005\u548c\u65b9\u6848\u8b8a\u6578\uff08\u4f8b\u5982\u4ecb\u5165\u3001\u5291\u91cf\u6216\u6301\u7e8c\u6642\u9593\uff09\u7684\u63cf\u8ff0\u4e0d\u5145\u5206\uff0c\u59a8\u7919\u7814\u7a76\u8907\u88fd<\/li>\n\n\n\n
  3. \u7814\u7a76\u5305\u62ec\u5177\u6709\u8a8d\u77e5\u554f\u984c\u5ee3\u6cdb\u6f5b\u5728\u539f\u56e0\u7684\u53c3\u8207\u8005: \u7406\u8ad6\u4e0a\uff0c\u8a72\u5354\u8b70\u91dd\u5c0d\u7684\u662f\u963f\u8332\u6d77\u9ed8\u75c7\u3002\u7136\u800c\uff0c\u7814\u7a76\u7121\u6cd5\u8a55\u4f30\u5c0d\u5e38\u898b\u795e\u7d93\u75c5\u7406\u904e\u7a0b\u7684\u5f71\u97ff<\/li>\n\n\n\n
  4. \u95dc\u65bc\u5982\u4f55\u9032\u884c\u548c\u8a55\u4f30\u8a8d\u77e5\u6e2c\u8a66\u6e2c\u91cf\u7684\u8cc7\u8a0a\u6709\u9650: \u63d0\u51fa\u9019\u6a23\u7684\u554f\u984c\uff1a\u53c3\u8207\u8005\u5728\u8a8d\u77e5\u6e2c\u91cf\u65b9\u9762\u7684\u6539\u5584\u662f\u5426\u53cd\u6620\u4e86\u771f\u5be6\u7684\u8b8a\u5316\u3001\u5076\u7136\u6027\u7684\u8b8a\u5316\uff0c\u9084\u662f\u7531\u65bc\u7df4\u7fd2\u6548\u679c\u800c\u63d0\u9ad8\u7684\u8868\u73fe<\/li>\n\n\n\n
  5. 2018 \u5e74\u8ad6\u6587\u5305\u542b\u4e00\u9805\u672a\u7d93\u6587\u737b\u9a57\u8b49\u7684\u6e2c\u8a66\u63aa\u65bd: \u5de5\u5177\u662f\u5426\u80fd\u5920\u6e2c\u91cf\u6240\u9700\u8b8a\u6578\u7684\u4e0d\u78ba\u5b9a\u6027<\/li>\n\n\n\n
  6. \u5831\u544a\u4e2d\u5c0d\u7814\u7a76\u9650\u5236\u7684\u8a0e\u8ad6\u53d7\u5230\u9650\u88fd\u6216\u6c92\u6709\u8a0e\u8ad6: \u4e0d\u8981\u5411\u8b80\u8005\u5c0d\u64ec\u8b70\u7684\u79d1\u5b78\u767c\u73fe\u9032\u884c\u5e73\u8861\u7684\u8a55\u4f30\uff0c\u9019\u53ef\u80fd\u6703\u5f15\u5165\u504f\u898b<\/li>\n\n\n\n
  7. 2018 \u5e74\u5831\u544a\u4e2d\u672a\u63ed\u9732\u7684\u8ca1\u52d9\u5229\u76ca\u885d\u7a81: \u4f5c\u8005\u6709\u53ef\u80fd\u5c0d\u8b80\u8005\u4e0d\u660e\u986f\u7684\u65e2\u5b9a\u7814\u7a76\u7d50\u679c\u7522\u751f\u81ea\u767c\u6027\u7684\u8208\u8da3\uff1b\u9650\u5236\u4e86\u8b80\u8005\u5728\u66f4\u5ee3\u6cdb\u7684\u80cc\u666f\u4e0b\u8a55\u4f30\u6240\u63d0\u4f9b\u6578\u64da\u7684\u80fd\u529b<\/li>\n\n\n\n
  8. \u6587\u7ae0\u51fa\u73fe\u5728\u63a0\u596a\u6027\u958b\u653e\u53d6\u7528\u671f\u520a \u6216\u88ab\u8a8d\u5b9a\u70ba\u63a0\u596a\u6027\u7684\u51fa\u7248\u5546\u4e2d: \u63a0\u596a\u6027\u671f\u520aPredatory journals<\/a> \u53ef\u4ee5\u767c\u8868\u4f4e\u54c1\u8cea\u7684\u79d1\u5b78\u5831\u544a\uff0c\u53ef\u80fd\u8aa4\u5c0e\u8b80\u8005\u95dc\u65bc\u7814\u7a76\u7684\u56b4\u8b39\u6027<\/li>\n<\/ol>\n\n\n\n

    \u5177\u9ad4\u4f86\u8aaa\uff0c\u9019\u4e9b\u6587\u7ae0\u5747\u4e0d\u5305\u542b\u65b9\u6cd5\u90e8\u5206\uff0c\u56e0\u6b64\u8b80\u8005\u4e0d\u6703\u88ab\u544a\u77e5\u65b9\u6848\u7684\u76f8\u95dc\u65b9\u9762\uff08\u4f8b\u5982\uff0c\u9075\u5faa\u4e86\u54ea\u4e9b\u65b9\u6848\u8981\u7d20\u3001\u5291\u91cf\u548c\u6301\u7e8c\u6642\u9593\u662f\u591a\u5c11\uff09\uff0c\u4e26\u4e14\u9019\u4e9b\u7814\u7a76\u7121\u6cd5\u91cd\u8907\u3002\u6b64\u5916\uff0c\u9019\u4e9b\u8ad6\u6587\u6c92\u6709\u50b3\u9054\u53c3\u8207\u8005\u7684\u7d0d\u5165\u548c\u6392\u9664\u6a19\u6e96\uff0c\u9019\u5c07\u70ba\u53ef\u80fd\u7684\u9078\u64c7\u504f\u5dee\u53ca\u5176\u7a0b\u5ea6\u63d0\u4f9b\u66f4\u591a\u80cc\u666f \u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728 2018 \u5e74\u767c\u8868\u7684\u8ad6\u6587\u4e2d\uff0c100 \u540d\u53c3\u8207\u8005\u63a5\u53d7\u4e86 Bredesen \u65b9\u6848\u63cf\u8ff0\u7684\u5e72\u9810\u63aa\u65bd\uff0c\u64da\u5831\u5c0e\u6240\u6709\u53c3\u8207\u8005\u7684\u75c5\u60c5\u90fd\u6709\u6240\u6539\u5584\u3002\u6c92\u6709\u63d0\u4f9b\u4efb\u4f55\u7121\u53cd\u61c9\u8005\u7684\u6578\u64da\uff0c\u4e5f\u6c92\u6709\u63d0\u4f9b\u6709\u95dc\u8a3a\u65b7\u6a19\u6e96\u4f7f\u7528\u7684\u8cc7\u8a0a\u3002\u7e3d\u7684\u4f86\u8aaa\uff0c\u9019\u4e9b\u8b66\u544a\u9650\u5236\u4e86\u6211\u5011\u5c0d\u7d50\u679c\u7684\u4e00\u822c\u80fd\u529b\u7684\u7406\u89e3\u3002\u8b80\u8005\u88ab\u544a\u77e5\uff0c\u7814\u7a76\u4e2d\u5305\u62ec\u6709\u4e3b\u89c0\u8a8d\u77e5\u969c\u7919\u6216\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919\u7684\u53c3\u8207\u8005\uff1b\u7136\u800c\uff0c\u9019\u5169\u7a2e\u60c5\u6cc1\u90fd\u53ef\u80fd\u6709\u8207\u795e\u7d93\u9000\u5316\u904e\u7a0b\u7121\u95dc\u7684\u539f\u56e0\u3002\u56e0\u6b64\uff0c\u6b63\u5982\u8ad6\u6587\u6240\u6697\u793a\u7684\u90a3\u6a23\uff0c\u9019\u4e9b\u7814\u7a76\u4e26\u4e0d\u662f\u91dd\u5c0d\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u5e38\u898b\u6f5b\u5728\u795e\u7d93\u75c5\u7406\u904e\u7a0b\u3002\u81e8\u5e8a\u7814\u7a76\u7684\u5176\u4ed6\u57fa\u672c\u8981\u7d20\u4e26\u672a\u51fa\u73fe\u5728\u51fa\u7248\u7269\u4e2d\uff0c\u4f8b\u5982\u5982\u4f55\u9032\u884c\u548c\u8a55\u4f30\u6e2c\u8a66\u63aa\u65bd\u7684\u89e3\u91cb\u3002\u5c0d\u65bc\u8a8d\u77e5\u8a55\u4f30\uff0c\u9019\u7a2e\u907a\u6f0f\u63d0\u51fa\u4e86\u9019\u6a23\u7684\u554f\u984c\uff1a\u795e\u7d93\u5fc3\u7406\u5b78\u6e2c\u9a57\u5206\u6578\u7684\u6539\u5584\u662f\u5426\u53cd\u6620\u4e86\u4ecb\u5165\u9020\u6210\u7684\u771f\u5be6\u8b8a\u5316\uff0c\u662f\u7531\u65bc\u8868\u73fe\u7684\u5076\u7136\u8b8a\u5316\uff0c\u9084\u662f\u91cd\u8907\u6e2c\u9a57\u7684\u7df4\u7fd2\u6548\u679c\u9020\u6210\u7684\u3002\u4e8b\u5be6\u4e0a\uff0c\u8a31\u591a\u6709\u4e3b\u89c0\u8a8d\u77e5\u62b1\u6028\u7684\u4eba\u9810\u671f\u6703\u5728\u8a8d\u77e5\u6e2c\u9a57\u4e2d\u8868\u73fe\u51fa\u5be6\u8e10\u6548\u679c\u3002\u5728 2018 \u5e74\u7684\u8ad6\u6587\u4e2d\uff0c\u4f7f\u7528\u4e86\u6240\u8b02\u7684\u5fc3\u7406\u75c7\u72c0\u554f\u5377\uff0c\u986f\u7136\u662f\u67d0\u7a2e 284 \u9ede\u7684\u8a8d\u77e5\u8a55\u4f30\uff0c\u5118\u7ba1\u8a72\u5de5\u5177\u6c92\u6709\u5728 PubMed <\/a>\u4e2d\u5f15\u7528\u6216\u7d22\u5f15\uff0c\u9019\u8b93\u4eba\u8cea\u7591\u8a72\u5de5\u5177\u6e2c\u91cf\u671f\u671b\u7684\u6709\u6548\u6027\u8b8a\u6578\u3002<\/p>\n\n\n\n

    2018 \u5e74\u8ad6\u6587\u4e2d\u7684 11 \u7bc7\u53c3\u8003\u6587\u737b\u4e2d\u6709 7 \u7bc7\u4f86\u81ea Dale Bredesen \u81ea\u5df1\u7684\u8457\u4f5c\u3002\u9019\u4e09\u7bc7\u6587\u7ae0\u6c92\u6709\u5305\u542b\u5c0d\u7814\u7a76\u9650\u5236\u7684\u5fb9\u5e95\u8a0e\u8ad6\u3002\u4e09\u7bc7\u8ad6\u6587\u4e2d\u53ea\u6709\u5169\u7bc7\u627f\u8a8d\u9019\u4e9b\u767c\u73fe\u7684\u521d\u6b65\u6027\u8cea\uff0c\u4e26\u547c\u7c72\u5c0d\u8a72\u65b9\u6848\u9032\u884c\u5c0d\u7167\u7814\u7a76\u3002\u5728 ClinicalTrials.gov<\/a> \u4e0a\uff0c\u5831\u544a\u4e86\u4e00\u9805\u6b63\u5728\u7a4d\u6975\u62db\u52df Bredesen \u65b9\u6848\u7684\u7814\u7a76\uff08\u8a8d\u77e5\u8870\u9000\u7684\u9006\u8f49\uff0cNCT03883633<\/a>\uff09\uff0c\u4e26\u88ab\u5217\u70ba\u4e00\u9805\u50c5\u75c5\u4f8b\u89c0\u5bdf\u6027\u7814\u7a76\uff0c\u6c92\u6709\u5c0d\u7167\u7d44\u3001\u96a8\u6a5f\u5316\u6216\u89e3\u91cb\u5b89\u6170\u5291\u6548\u61c9\u7684\u7814\u7a76\u6a5f\u5236\u3002<\/p>\n\n\n\n

    \u8b80\u8005\u53ef\u80fd\u4e0d\u77e5\u9053\u8a55\u4f30 Bredesen \u65b9\u6848\u7684\u4e09\u500b\u6848\u4f8b\u7cfb\u5217\u51fa\u73fe\u5728\u4e00\u4e9b\u88ab\u4e00\u4e9b\u4eba\u8a8d\u70ba\u662f\u63a0\u596a\u6027\u958b\u653e\u53d6\u7528\u671f\u520a\u7684\u671f\u520a\u4e2d\u3002\u63a0\u596a\u6027\u958b\u653e\u53d6\u7528\u671f\u520a\u662f\u807d\u8d77\u4f86\u5f88\u79d1\u5b78\u7684\u51fa\u7248\u7269\uff0c\u5b83\u5011\u52ab\u6301\u958b\u653e\u53d6\u7528\u6a21\u5f0f\u4ee5\u7372\u5f97\u5229\u6f64\u3002\u5171\u540c\u7684\u7279\u9ede\u901a\u5e38\u662f\u4f5c\u8005\u7684\u51fa\u7248\u8cbb\u7528\u5f88\u9ad8\uff0c\u800c\u5728\u6587\u7ae0\u5167\u5bb9\u548c\u54c1\u8cea\u65b9\u9762\u7684\u7de8\u8f2f\u8cbb\u7528\u5f88\u4f4e\u751a\u81f3\u4e0d\u5b58\u5728\u3002\u767c\u8868\u524d\u5169\u7bc7\u6587\u7ae0\u7684\u300a Aging<\/em><\/a>\u300b<\/em>\u96dc\u8a8c\u51fa\u73fe\u5728 Beall<\/a> \u7684\u6f5b\u5728 \u3001\u53ef\u80fd\u6216\u53ef\u80fd\u7684\u63a0\u596a\u6027\u958b\u653e\u7372\u53d6\u671f\u520a\u5217\u8868\u4e2d\uff0c\u8a72\u5217\u8868\u7531\u5b78\u8853\u5716\u66f8\u9928\u54e1 Jeffrey Beall \u7de8\u5236\u3002 OMICS International<\/a> \u662f\u300a<\/em>\u963f\u8332\u6d77\u9ed8\u75c7\u8207\u5e15\u91d1\u68ee\u6c0f\u75c7\u96dc\u8a8c The Journal of Alzheimer\u2019s Disease & Parkinsonism<\/em><\/a>\u300b<\/em>\u7684\u51fa\u7248\u5546\uff0c\u7b2c\u4e09\u7bc7\u6587\u7ae0\u5c31\u662f\u5728\u8a72\u96dc\u8a8c\u4e0a\u767c\u73fe\u7684\uff0c\u8a72\u51fa\u7248\u5546\u5df2\u88ab\u8a8d\u5b9a\u70ba\u63a0\u596a\u6027\u51fa\u7248\u5546\u3002 OMICS International \u6700\u8fd1\u56e0\u6b3a\u9a19\u6027\u5546\u696d\u884c\u70ba\uff08\u5305\u62ec\u300c\u8aa4\u5c0e\u4f5c\u8005\u4e86\u89e3\u5176\u671f\u520a\u7684\u5408\u6cd5\u6027\u300d\uff09\u800c\u88ab\u7f8e\u570b\u806f\u90a6\u8cbf\u6613\u59d4\u54e1\u6703\u8655\u4ee5 5000 \u842c\u7f8e\u5143\u7f70\u6b3e\u3002<\/p>\n\n\n\n

    \u8003\u616e\u5230\u9019\u4e9b\u56e0\u7d20\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f Bredesen \u65b9\u6848\u5df2\u7d93\u5546\u696d\u5316\uff1b\u7136\u800c\uff0c\u4f5c\u8005\u4e26\u672a\u5728\u5176\u79d1\u5b78\u5831\u544a\u4e2d\u63ed\u9732\u4efb\u4f55\u5229\u76ca\u885d\u7a81\u3002\u5118\u7ba1\u8a72\u5831\u544a\u662f\u5728 2017 \u5e74\u8a72\u66f8\u51fa\u7248\u5f8c\u767c\u5e03\u7684\uff0c\u4f46 2018 \u5e74\u7684\u8ad6\u6587\u4e26\u672a\u5305\u542b\u5229\u76ca\u885d\u7a81\u8072\u660e\u3002\u8a72\u516c\u53f8\u63d0\u4f9b Bredesen \u65b9\u6848\u8a55\u4f30\u3001\u5be6\u9a57\u5ba4\u6e2c\u8a66\u4ee5\u53ca\u63a5\u53d7\u8a13\u7df4\u6709\u7d20\u7684\u5f9e\u696d\u4eba\u54e1\u7684\u8a2a\u554f\uff0c\u8cbb\u7528\u70ba 1399 \u7f8e\u5143\uff08\u6253\u5305\u70ba ReCODE\uff09\uff0c\u4ee5\u53ca\u6bcf\u6708\u8a02\u95b1\u8a08\u5283\uff0c\u5305\u62ec\u8a8d\u77e5\u904a\u6232\u548c\u984d\u5916\u6536\u8cbb\u7684\u5728\u7dda\u652f\u6301\u3002\u6b64\u5916\uff0cApollo Health <\/a>\u6253\u7b97\u70ba\u91ab\u751f\u63d0\u4f9b\u6210\u70ba\u8a8d\u8b49\u65b9\u6848\u63d0\u4f9b\u8005\u7684\u8ab2\u7a0b\u3002 Apollo Health \u7db2\u7ad9\u9084\u9023\u7d50\u5230 LifeSeasons.com\/recode<\/a>\uff0c\u5176\u4e2d\u300c\u8207 Dale Bredesen \u5408\u4f5c\u300d\u70ba\u8a72\u65b9\u6848\u958b\u767c\u7684\u5ba2\u88fd\u5316\u81b3\u98df\u88dc\u5145\u5291\u6bcf\u6708\u552e\u50f9\u8d85\u904e 150 \u7f8e\u5143\u3002\u8a72\u516c\u53f8\u7db2\u7ad9\u5305\u542b  \u201c\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u7b2c\u4e00\u500b\u771f\u6b63\u5e0c\u671b First Real Hope for Alzheimer\u2019s\u201d \u548c \u201c\u79d1\u5b78\u5e36\u4f86\u5e0c\u671b Hope through Science\u201d \u7684\u8072\u660e\u3002<\/p>\n\n\n\n

    Bredesen \u65b9\u6848\u7684\u67d0\u4e9b\u8981\u7d20\u53ef\u80fd\u662f\u6709\u76ca\u7684\uff0c\u4e26\u4e14\u57fa\u672c\u4e0a\u5c0d\u60a3\u8005\u514d\u8cbb\u3002\u7661\u5446\u75c7\u8a3a\u6240\u7684\u8b77\u7406\u6a19\u6e96\u662f\u514d\u8cbb\u6559\u80b2\u60a3\u8005\u9032\u884c\u5927\u8166\u5065\u5eb7\u7684\u751f\u6d3b\u65b9\u5f0f\u4e7e\u9810\uff0c\u9019\u4e9b\u5e72\u9810\u63aa\u65bd\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u5f97\u5230\u4e86\u79d1\u5b78\u6587\u737b\u7684\u652f\u6301\uff0c\u5305\u62ec\u6709\u6c27\u904b\u52d5\u3001\u5730\u4e2d\u6d77\u98f2\u98df\u3001\u793e\u4ea4\u548c\u8a8d\u77e5\u53c3\u8207\u4ee5\u53ca\u8166\u8840\u7ba1\u7684\u7ba1\u7406\u98a8\u96aa\u56e0\u7d20\u3002\u5065\u5eb7\u4fdd\u96aa\u901a\u5e38\u627f\u4fdd\u8a8d\u77e5\u6539\u8b8a\u7684\u53ef\u9006\u539f\u56e0\u7684\u6aa2\u6e2c\uff0c\u4f8b\u5982\u7532\u72c0\u817a\u75be\u75c5\u3001\u7dad\u751f\u7d20 B12 \u7f3a\u4e4f\u6216\u7761\u7720\u547c\u5438\u4e2d\u6b62\u75c7\u3002Bredesen \u65b9\u6848\u4e2d\u5c1a\u672a\u88ab\u8b49\u660e\u5c0d\u5927\u8166\u5065\u5eb7\u6709\u6548\u7684\u4e00\u4e9b\u5167\u5bb9\u662f\u5bc6\u96c6\u4e14\u6602\u8cb4\u7684\u81b3\u98df\u88dc\u5145\u5291\u7642\u6cd5\u3002\u6700\u8fd1\u7684\u4e00\u4efd\u570b\u969b\u5171\u8b58\u6587\u4ef6\u5f97\u51fa\u7684\u7d50\u8ad6\u662f\uff0c\u201c\u5c1a\u672a\u8b49\u660e\u88dc\u5145\u5291\u53ef\u4ee5\u5ef6\u7de9\u7661\u5446\u75c7\u7684\u767c\u4f5c\uff0c\u4e5f\u4e0d\u80fd\u9810\u9632\u3001\u6cbb\u7642\u6216\u9006\u8f49\u963f\u8332\u6d77\u9ed8\u75c7\u6216\u5176\u4ed6\u5c0e\u81f4\u7661\u5446\u75c7\u7684\u795e\u7d93\u7cfb\u7d71\u75be\u75c5<\/a>\u201d ( Ref. The Guardian<\/a>, ‘Save your money’: no evidence brain health supplements work, say experts. 2019\/jun\/29) \u3002<\/p>\n\n\n\n

    \u7576\u770b\u5230\u9019\u4e9b\u8cc7\u8a0a\u6642\uff0c\u6709\u4e9b\u4eba\u4ecd\u7136\u5805\u4fe1\u8a72\u65b9\u6848\u7684\u6709\u6548\u6027\u3002\u4fe1\u5ff5\u7684\u5f62\u6210\u78ba\u5be6\u662f\u4e00\u500b\u8907\u96dc\u7684\u904e\u7a0b\uff0c\u5fc3\u7406\u5b78\u5bb6\u548c\u79d1\u5b78\u54f2\u5b78\u5bb6\u5df2\u7d93\u5c0d\u6b64\u9032\u884c\u4e86\u63a2\u7d22\u3002\u4e26\u975e\u6211\u5011\u6240\u6301\u6709\u7684\u6240\u6709\u4fe1\u5ff5\u90fd\u6703\u53d7\u5230\u56b4\u683c\u7684\u61f7\u7591\uff0c\u4e5f\u4e26\u975e\u6240\u6709\u4fe1\u5ff5\u90fd\u662f\u7531\u4e8b\u5be6\u8cc7\u8a0a\u5851\u9020\u7684\u3002\u61f7\u7591\u662f\u79d1\u5b78\u8aa0\u4fe1\u7684\u6838\u5fc3\u7279\u5fb5\uff0c\u5728\u8a55\u4f30\u6f5b\u5728\u7684\u91ab\u7642\u5e72\u9810\u63aa\u65bd\u6642\u81f3\u95dc\u91cd\u8981\u3002\u6211\u5011\u9700\u8981\u63d0\u51fa\u4e00\u4e9b\u65b9\u6cd5\u4f86\u89e3\u6c7a\u60a3\u8005\u95dc\u65bc\u6b64\u985e\u5e72\u9810\u63aa\u65bd\u7684\u554f\u984c\uff0c\u4ee5\u53ca\u7576\u60a3\u8005\u7684\u4fe1\u5ff5\u53ef\u80fd\u4e0d\u662f\u7531\u4e8b\u5be6\u8cc7\u8a0a\u5f62\u6210\u6216\u5c0d\u65b0\u6578\u64da\u6c92\u6709\u53cd\u61c9\u6642\u5982\u4f55\u8207\u60a3\u8005\u6e9d\u901a\u3002\u91ab\u751f\u7d93\u5e38\u932f\u8aa4\u5730\u8a8d\u70ba\u75c5\u4eba\u53ea\u9700\u8981\u63a5\u53d7\u67d0\u500b\u4e3b\u984c\u7684\u6559\u80b2\u5373\u53ef\u6539\u8b8a\u4ed6\u5011\u7684\u4fe1\u5ff5\u548c\u884c\u70ba\uff1b\u76f8\u53cd\uff0c\u771f\u6b63\u7684\u8cac\u4efb\u662f\u6839\u64da\u60a3\u8005\u7684\u4fe1\u5ff5\u548c\u770b\u6cd5\u4f86\u6eff\u8db3\u4ed6\u5011\u7684\u9700\u6c42\u3002<\/p>\n\n\n\n

    \u4ed4\u7d30\u6aa2\u67e5\u5f8c\uff0c\u652f\u6301 Bredesen \u65b9\u6848\u7684\u79d1\u5b78\u7814\u7a76\u4e2d\u51fa\u73fe\u4e86\u591a\u500b\u5371\u96aa\u8a0a\u865f\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u8b49\u64da\u4e26\u4e0d\u652f\u6301\u5176\u9810\u9632\u548c\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u4e3b\u5f35\u3002\u9762\u5c0d\u4e0d\u6cbb\u4e4b\u75c7\uff0c\u5e0c\u671b\u5f88\u91cd\u8981\uff0c\u76f4\u89ba\u7684\u5e72\u9810\u63aa\u65bd\u53ef\u80fd\u6703\u4ee4\u4eba\u4fe1\u670d\u3002\u7136\u800c\uff0c\u4e0d\u53d7\u652f\u6301\u7684\u5e72\u9810\u63aa\u65bd\u5728\u91ab\u5b78\u4e0a\u3001\u9053\u5fb7\u4e0a\u6216\u7d93\u6fdf\u4e0a\u90fd\u4e0d\u662f\u826f\u6027\u7684\uff0c\u7279\u5225\u662f\u7576\u5176\u4ed6\u65b9\u53ef\u80fd\u53d7\u76ca\u6642\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u7576\u9762\u5c0d\u76ee\u524d\u7121\u6cd5\u6cbb\u7652\u7684\u75be\u75c5\uff08\u4f8b\u5982\u963f\u8332\u6d77\u9ed8\u75c7\uff09\u6642\uff0c\u60a3\u8005\u548c\u5bb6\u4eba\u901a\u5e38\u6703\u5728\u91ab\u751f\u8fa6\u516c\u5ba4\u4e4b\u5916\u5c0b\u627e\u5e0c\u671b\u3002\u8a3a\u65b7\u7d50\u679c\u53ef\u80fd\u6703\u4ee4\u4eba\u6050\u61fc\uff0c\u53ef\u4ee5\u7406\u89e3\u7684\u662f\uff0c\u6709\u4e9b\u4eba\u6703\u7a4d\u6975\u5c0b\u6c42\u4efb\u4f55\u8072\u7a31\u6709\u6548\u7684\u5e72\u9810\u63aa\u65bd\u3002\u96a8\u8457\u76f4\u63a5\u9762\u5411\u6d88\u8cbb\u8005\u7684\u7661\u5446\u75c7\u5e72\u9810\u63aa\u65bd\u84ec\u52c3\u767c\u5c55\uff0c\u56e0\u6b64\u9700\u8981\u56b4\u683c\u8a55\u4f30\u652f\u6301\u9019\u4e9b\u9078\u64c7\u7684\u8b49\u64da\u3002 Dale Bredesen \u6240\u8457\u7684 \u201cThe End of Alzheimer’s Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age\u201d \u4e00\u66f8\u56de\u9867\u4e86\u4ed6\u7684\u540c\u540d\u65b9\u6848 Bredesen Protocol\uff0c\u526f\u6a19\u984c\u662f \u201c\u7b2c\u4e00\u500b\u9810\u9632\u548c\u9006\u8f49\u8a8d\u77e5\u8870\u9000\u7684\u8a08\u5283\u201d\u3002Bredesen \u65b9\u6848\u63d0\u4f9b\u4e86\u4e00\u500b\u5c07\u591a\u7a2e\u81b3\u98df\u88dc\u5145\u5291\u8207\u8a73\u7d30\u7684\u751f\u6d3b\u65b9\u5f0f\u6539\u8b8a\u548c\u5176\u4ed6\u6709\u91dd\u5c0d\u6027\u7684\u5e72\u9810\u63aa\u65bd\uff08\u4f8b\u5982\u5c0d\u6297\u767c\u708e\u548c\u6bd2\u7d20\uff09\u76f8\u7d50\u5408\u7684\u8a08\u5283\u3002\u5118\u7ba1\u5be6\u65bd\u7684\u81ea\u4ed8\u8cbb\u7528\u5f88\u9ad8\uff0c\u4f46\u8a72\u65b9\u6848\u5df2\u7d93\u8d8a\u4f86\u8d8a\u53d7\u6b61\u8fce\uff0c\u800c\u4e14\u8a72\u66f8\u51fa\u73fe\u5728\u8a31\u591a\u66a2\u92b7\u66f8\u6392\u884c\u699c\u4e0a\uff0c\u5305\u62ec\u300a\u7d10\u7d04\u6642\u5831\u300b\u3001\u300a\u83ef\u723e\u8857\u65e5\u5831\u300b\u548c\u4e9e\u99ac\u905c\u7db2\u7ad9\u3002\u63a8\u85a6 Bredesen \u65b9\u6848\u7684\u91ab\u751f\u7d93\u5e38\u5f15\u7528 Bredesen \u767c\u8868\u7684\u4e09\u9805\u7814\u7a76\uff0c\u4ee5\u53ca\u4ed6\u8207\u53d7\u4eba\u5c0a\u656c\u7684\u5b78\u8853\u91ab\u7642\u4e2d\u5fc3\u7684\u95dc\u4fc2\u3002\u5118\u7ba1\u6c92\u6709\u5176\u4ed6\u65b9\u6cd5\u88ab\u8b49\u660e\u53ef\u4ee5\u660e\u78ba\u9810\u9632\u6216\u9006\u8f49\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\uff0c\u4f46 Bredesen \u65b9\u6848\u5f37\u70c8\u8072\u7a31\u5176\u529f\u6548 \uff1b\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u4ed4\u7d30\u8a55\u4f30\u73fe\u6709\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u78ba\u5b9a\u6307\u5c0e\u65b9\u6848\u7684\u8b49\u64da\u5f37\u5ea6 \u3002 I. \u201cThe End of Alzheimer’s Program\u201d … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[11,17],"tags":[],"class_list":["post-9310","post","type-post","status-publish","format-standard","hentry","category--thinking","category--read"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pc7IvU-2qa","_links":{"self":[{"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/posts\/9310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/comments?post=9310"}],"version-history":[{"count":1,"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/posts\/9310\/revisions"}],"predecessor-version":[{"id":9311,"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/posts\/9310\/revisions\/9311"}],"wp:attachment":[{"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/media?parent=9310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/categories?post=9310"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/philosophers.org\/ckf\/wp-json\/wp\/v2\/tags?post=9310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}